We aimed to investigate the molecular epidemic characteristics and viral transmission patterns of HIV-1 in a typical labor export area, Guangyuan city, China.
Based on conducting phylogenetic trees and molecular transmission networks, a phylogenetic analysis was performed on HIV-1 pol sequences obtained from migrant-history workers, 83 non-migrant-history individuals, and 21 migrant-history unknown individuals between January, and February, in Guangyuan city.
Geographic network analysis showed that Guangyuan city-related sequences with Our results highlighted that migrant-history workers in recent year played a vital role in fueling HIV-1 epidemic in Guangyuan city. Molecular transmission network analysis could be a useful approach for disclosing the transmission mechanism of HIV, which should be used in prevention and intervention efforts.
Among the , newly diagnosed HIV-1 infections in , One of the current challenges was that China faced the rapid increase of HIV-1 prevalence among floating population and lacking effective intervention strategies for this group 2 , 3. With the rapid urbanization of China, outgoing migrant-workers had become the main component of the floating population in China, who worked outside the place where the household registrations were located 4. The migrant-workers accounting for a large proportion of HIV-1 epidemic in China had caused the diversity of circulating HIV-1 and could further local fuel epidemics 5 , 6.
Although several molecular epidemiological investigations conducted in Shanghai, Beijing, Shenzhen, and others indicated that migrant-workers had a significant influence on the HIV-1 epidemics in coastal or metropolis 2 , 7 , 8 , barely researches focused on the condition of rural areas where export labors.
